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Herpes & Herpes Zoster (Shingles)
 


Genital Herpes

Genital herpes is a sexually transmitted disease (STD) that produces blisters and skin ulcers in the genital area. It can be caused by either one of two types of herpes simplex virus, HSV-1 or HSV-2. HSV-2 is the more common culprit. HSV spreads from person to person through kissing and skin-to-skin contact, as well as through vaginal, oral or anal intercourse. An infected person can transmit the virus during times when skin blisters or ulcers are visible, but he or she also can spread the virus when there are no symptoms at all. The virus also can be transmitted by people who are unaware that they are infected.

In a pregnant woman with HSV infection (usually HSV-2), the virus can pass to the baby during delivery, causing infections of the newborn's skin, mouth, lungs or eyes. If the herpes virus spreads through the baby's bloodstream, serious infections of the brain and other vital organs also can occur.

According to government health experts, approximately 45 million people in the United States older than age 12 are infected with HSV-2. Genital herpes, with or without symptoms, currently affects approximately one in every four females and one in every five males in the total population of U.S. adults and adolescents between ages 15 and 45. Within the past two decades, the number of genital herpes infections has increased significantly among Americans, with the most dramatic increases seen in adolescents and young adults.

Symptoms
Most people with an HSV-2 infection have no symptoms. When symptoms appear, they are usually mild and can include itching, burning, soreness and small blisters in the genital area; small ulcers (skin sores) when the blisters break; local pain if urine contacts the genital ulcers; enlarged and/or painful lymph nodes (swollen glands) in the groin; headache, fever and a generally sick feeling. In some people with genital herpes, cold sores or fever blisters also can erupt around the mouth. In general, symptoms of genital herpes appear approximately one week after being exposed to someone with herpes infection.

The first episode of herpes symptoms is usually the worst. About 40 percent of infected people never have a second attack. Others, however, have four to five recurrences per year. In people who have recurrent herpes episodes, symptoms generally are most common after sexual intercourse, after sunbathing, and during times of physical or emotional stress.

In newborns who are infected with herpes during delivery, symptoms usually appear nine to 11 days after birth and can include skin blisters, red eyes and an abnormal eye discharge. If the virus spreads through the baby's bloodstream to the brain, there can be lethargy, irritability and seizures. If the virus spreads to the baby's lungs, the baby may have difficulty breathing and may need to be placed on a ventilator for breathing assistance.


Diagnosis
Your doctor can diagnose genital herpes based on your sexual history, your symptoms and the results of your physical examination. Your doctor may want to confirm the diagnosis by scraping the affected skin area for laboratory testing. Because people who have one type of STD are at risk for others, your doctor may wish to perform tests for other STDs, such as syphilis, gonorrhea, chlamydia, chancroid and human immunodeficiency virus (HIV).

Expected Duration

The HSV infection that causes genital herpes is a lifelong illness whose symptoms tend to recur. The pattern of recurrence is different for every person.

Prevention

To help prevent the spread of genital herpes, people who have the illness should abstain from sexual activity when they have symptoms of a herpes recurrence. They also should tell all sex partners about their herpes infection and use condoms during sexual activity. Even without symptoms, the virus still can be shed and transmitted.

Pregnant women who have visible ulcers from genital herpes at the time of delivery usually are encouraged to undergo Caesarean section to prevent HSV from spreading to her newborn. Because the decision for Caesarean section is based on many factors, a pregnant woman with HSV infection should discuss the subject with her physician as early as possible in her pregnancy. If a pregnant woman in her third trimester feels a recurrence of herpes coming on, she should call her doctor right away.

People with genital herpes are more likely to contract HIV infection if they are exposed through sexual intercourse. If you already have HIV, a simultaneous HSV-2 infection may make you more likely to spread HIV to others in high-risk situations.

Treatment
Episodes of genital herpes can be treated with oral anti-viral medications, including acyclovir (Zovirax), famciclovir (Famvir) and valacyclovir (Valtrex). These medications do not cure the herpes infection. They can shorten the duration of skin symptoms but most often are used to prevent symptoms from recurring or make recurrences less severe. When herpes infection spreads through the bloodstream and causes widespread infection, it can be treated with antiviral medication given intravenously (directly into the veins).

When To Call A Professional
Call your doctor if you have blisters or sores in your genital area, especially if you are pregnant or have frequent bouts of symptoms.

Prognosis

Although there currently is no cure for genital herpes, the frequency of recurrences often decreases with time. Daily oral antiviral medication also can decrease the number of recurrences by at least 75 percent in people with frequent herpes episodes (six or more recurrences per year).

Additional Information

American Social Health Association

P.O. Box 13827
100 Capitol Dr.
Research Triangle Park, NC 27709-3827
Phone: (919) 361-8400
Fax: (919) 361-8425
http://www.ashastd.org/

Last updated November 05, 2002


What is Shingles?
Shingles is an infection caused by the varicella-zoster virus, which is the virus that causes chickenpox. Shingles occurs in people who have had chickenpox and represents a reactivation of the dormant varicella-zoster virus. The disease generally affects the elderly, although it occasionally occurs in younger and/or immunodeficient individuals. The first sign is usually a tingling feeling, itchiness, or stabbing pain on the skin. After a few days, a rash appears as a band or patch of raised dots on the side of the trunk or face. The rash develops into small, fluid-filled blisters which begin to dry out and crust over within several days. When the rash is at its peak, symptoms can range from mild itching to extreme and intense pain. Contact with a person with shingles may cause chickenpox (but not shingles) in someone who has never had chickenpox before.

Is there any treatment?

Treatment for shingles includes antiviral drugs, steroids, antidepressants, anticonvulsants, and topical agents. The severity and duration of an attack of shingles can be significantly reduced by immediate treatment with the antiviral drugs acyclovir, valacyclovir or famcyclovir. These drugs may also help stave off the painful aftereffects of shingles known as postherpetic neuralgia.
What is the prognosis?
Although shingles can be very painful and itchy, it is not generally dangerous to healthy individuals and it usually resolves without complications. The rash and pain usually go away within 3 to 5 weeks. Sometimes serious effects including partial facial paralysis (usually temporary), ear damage, or encephalitis (inflammation of the brain) may occur. Persons with shingles on the upper half of the face should seek medical attention immediately as the virus may cause serious damage to the eyes. Most people who have shingles have only one bout with the disease in their lifetime. However, individuals with impaired immune systems, i.e., people with AIDS or cancer, may suffer repeated episodes.
What research is being done?
The NINDS conducts and supports a program of research aimed at developing new treatments for and preventing the painful conditions of shingles.

Select this link to view a list of studies currently seeking patients.

Organizations

American Chronic Pain Association (ACPA)

P.O. Box 850
Rocklin, CA 95677-0850
ACPA@pacbell.net
http://www.theacpa.org
Tel: 916-632-0922 800-533-3231
Fax: 916-632-3208

National Chronic Pain Outreach Association (NCPOA)
P.O. Box 274
Millboro, VA 24460
ncpoa@cfw.com
http://www.chronicpain.org
Tel: 540-862-9437
Fax: 540-862-9485

VZV Research Foundation [For Research on Varicella Zoster]

40 East 72nd Street
New York, NY 10021
vzv@vzvfoundation.org
http://www.vzvfoundation.org
Tel: 212-472- 3181 800-472-VIRUS (8478)
Fax: 212-861-7033

National Foundation for the Treatment of Pain
1330 Skyline Drive
#21
Monterey, CA 93940
markgordon@paincare.org
http://www.paincare.org
Tel: 831-655-8812
Fax: 831-655-2823

Related NINDS Publications and Information
Shingles: Hope Through Research
An informational booklet on shingles compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Ramsay Hunt Syndrome Type I
Ramsay Hunt Syndrome Type I (Herpes Zoster Oticus) information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Pain: Hope Through Research
Information booklet on pain compiled by the National Institute of Neurological Disorders and Stroke (NINDS).



NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
This health article is made available by
Dr. Eliot Y Ghatan MD a Dermatologist. AESTHETIC SURGERY & DERMATOLOGY office at 1226 Ocean Parkway, Brooklyn, NY 11230. Dr. Ghatan is easy reachable from Breezy Point, Bronx, Brooklyn, Connecticut, Far Rockaway, Howard Beach, Long Island, Manhattan, New Jersey, Queens, Ridgewood, Rockaway Park, and Staten Island.
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